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Background: Elevated mean platelet volume may reflect presence of active large platelets, which lead to fatal or non-fatal cardiovascular events. In recent studies, lack of nocturnal blood pressure fall was presented as an independent predictor of poor prognosis in essential hypertension. The relation of raised MPV with left ventricular hypertrophy has also been reported in hypertension. The aim of this study was to investigate the relation between MPV, non-dipping blood pressure pattern, and left ventricular mass index (LVMI) in sustained hypertension.

As a consequence, we believe that the impairment of the cardiac autonomic nervous system function may be helpful in explaining the results of the article by Petta et al., [[1] ]. We hope that the above-mentioned items would add to the value of the well-written article of Petta et al. on the relationship between epicardial fat and NAFLD.