Burn-related renal failure is usually seen in the initial resuscitation period after burn injury or as a component of severe sepsis-related multi-organ failure. The main factors responsible for the development of early renal failure in the burn patient are hypovolemia or an ineffective perfusion gradient between the glomerulus and Bowman’s space. The basic mechanism for the glomerular pressure/filtration ratio is effective renal blood flow, which is controlled by the relative resistance between the afferent and efferent arterioles. The main causes of decreased GFR in the early period are: 1- Hypovolemia 2- Myocardial depression (cardiac beat) 3- Extrinsic compression due to abdominal compartment syndrome 4- Protein denaturation may occur.
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