Neuroprolotherapy is the newest step in regenerative medicine used to treat neuropathic pain and other painful conditions caused by damage to the musculoskeletal system. It is also called neurofacial prolotherapy, subcutaneous prolotherapy or lyfgot technique.
Neural prolotherapy is the subcutaneous injection of medical sugar or mannitol for the recovery of damaged-inflamed nerves and tissue function restoration.
Neural prolotherapy is based on Hilton’s law. In Hilton’s law, the nerves that innervate the joint also innervate the skin and muscles that move the joint.
Irritation of the sensory nerves of the skin over the joint causes pain and dysfunction in the tissues and muscles around the joint.
It is known that in classical prolotherapy, hypertonic dextrose provides improvement in connective tissue in ligaments and tendons. Neuroprolotherapy has also been shown to reduce swelling in the tissue, relieve pain and improve function.
In tissue injuries, proinflammatory substances (bradykinin, prostaglandin) are released and they activate the transient receptor potential V1 (TRPV1) cation channel (capsaicin) on the nerve. When these channels are opened, inflammation (substance P and CGRP) causes leakage in blood vessels. (swelling-oedema), hypersensitivity and painful sensation. Dextrose or mannitol block capsaicin receptors, prevent cascade and restore normal nerve function.
Neural prolotherapy is effective in the treatment of pain (whether acute or chronic) related to joint, muscle, tendon and ligament injuries. Treatment includes neck, waist, knee, shoulder, hip, elbow, wrist, hand, ankle joint. Pain after total knee replacement and failed back surgery is also effective.
Treatment is arranged 2-3 times a week. Session 10 – 15 min. between may be required.
