Ege University (EU) Faculty of Science Department of Biochemistry lecturer Assoc. Dr. The work of the project “Development of Specific DNA Aptamer for the Inhibition of Histone Deacetylase 10 (HDAC10) Activity” supported by TÜBİTAK within the framework of the international COST action, led by Serap Evran, continues. EU Rector Prof. Dr. Necdet Budak, Assoc. Dr. He congratulated Serap Evran and the project team and wished them success.
It is managed by Assoc. Dr. Studies for the development of a new single-stranded DNA molecule called aptamer against HDAC10 enzyme activity continue in the project, in which Ezgi Man, Ph. The aptamer to be obtained as a result of the project is aimed to contribute to chronic GVHD treatment studies as a potential drug candidate.
Providing information about the details of the project, Assoc. Dr. Serap Evran said, “Allogeneic hematopoietic stem cell transplantation is an important treatment option for diseases such as bone marrow failure, hemoglobin-induced blood diseases and thalassemia. For this, cells obtained from family members, non-family members or cord blood units are used. The most important complication of this treatment is graft versus host (GVHD) disease that may occur after transplantation. The cause of GVHD disease is that the donor’s white blood cells perceive the recipient cells as foreign.
Assoc. Dr. Serap Evran, “GVHD occurs in acute or chronic form. Despite advances in the prevention and treatment of acute GVHD, chronic GVHD affects many patients negatively and leads to death. Immunosuppressive drugs are used in the treatment of chronic GVHD. However, new treatment methods are needed because some patients do not respond to treatment and side effects caused by long-term drug use. The use of cells called regulatory T cells, which suppress the immune response, is promising in the treatment of chronic GVHD. A protein called Foxp3 is required for these cells to be used to treat GVHD. For the production of Foxp3 protein, new drugs are required to stop the activity of the enzyme called histone deacetylase 10 (HDAC10).
Source: (BYZHA) – Beyaz News Agency
