Lung cancer is the cause of more than half of cancer deaths each year. Familial risk is important in lung cancer, although the genetic basis of the disease is still unclear. The aim of the study is to investigate whether there is a familial predisposition for lung and non-lung cancer types in old and newly diagnosed lung cancer cases in the chest diseases clinic, and to investigate the relationship of this predisposition with demographic factors such as histopathological type, disease stage and gender.
Methods and Materials: The study included 350 newly and previously diagnosed patients with lung cancer who applied to the Chest Diseases Clinic between April 2013 and December 2014, and a control group consisting of 350 patients without lung cancer and/or any cancer. The gender, age, smoking status, pack-year of cigarettes, familial predispositions of the patients in terms of lung cancer and non-lung cancer types were recorded and the characteristics of both groups were compared. Results: We found that the risk of lung cancer was 2.18 and 3.14 times higher in first-degree and second-degree relatives with lung cancer compared to those with no family history, respectively.
