Antibiotic drugs used in the treatment of various diseases, unfortunately, still continue to be used without the authorization of a physician today. The unconscious use of antibiotic drugs that should be used under medical supervision can cause many risky situations such as aortic rupture! Cardiovascular Surgery Specialist from Istanbul University Istanbul Faculty of Medicine Prof. Dr. İhsan Bakır gave information about the unconsciously used antibiotics and the situations that may arise as a result.
Unconscious use of antibiotics can rupture the aorta
The US Food and Drug Administration FDA has issued a valuable warning about a cluster of antibiotics. These drugs of the “Fluoroquinolone” group should be used very carefully even under medical supervision in risky patients, because according to new studies, these antibiotics can cause aortic ruptures, which can be fatal!
Antibiotics are still one of the best options available to the medical world in the treatment of infections. However, some antibiotics, which are used “by heart” without medical supervision and without an antibiogram test, can even cause fatal pictures such as aortic rupture in risky patients. Aortic aneurysm, which also caused the death of artist Oya Aydoğan, is a deadly disease that progresses insidiously without any symptoms. Those who have high blood pressure, high cholesterol, sudden death in the family, blood pressure-related stroke or brain aneurysm, diabetes, fainting, aortic insufficiency, etc. in the family or in the patient themselves constitute the risky cluster in terms of aortic aneurysm. It is necessary to be very careful when using antibiotics in these patients.
May cause fatal bleeding!
The US Food and Drug Administration FDA issued an important alert on December 20 to concerned patients and healthcare professionals. Accordingly, the use of “fluoroquinolone” antibiotics, which are widely preferred in the treatment of lower respiratory tract infections such as urinary tract infections, bronchitis, and pneumonia, should be restricted in risky patient groups, and other drugs should be preferred if possible. Because these drugs cause changes in the DNA of smooth muscle cells and cause destruction of these muscles at the cell level.
This can cause thinning, ballooning and even rupture of the aorta, which can lead to fatal bleeding! He made valuable statements by stating that this warning issued by the FDA should be taken very seriously in terms of both patients and healthcare professionals. The Ministry of Health also warned about the risks of the musculoskeletal system.
FDA bases this warning on scientific studies conducted in 2015 and 2018. The latest research was featured in the respected medical journal JAMA on September 19, 2018, and the FDA then issued this warning. The unconscious or uncontrolled use of antibiotics is a dangerous situation as it mainly leads to resistant infections and causes an increase in antibiotic resistance in the society.
Although the information that it can cause aortic aneurysm and rupture is very new, it should be taken seriously in terms of its fatal risks. prof. Dr. İhsan Bakır pointed out that the Ministry of Health issued a warning regarding fluoroquinolone cluster antibiotics in 2017, and said, “The warning issued by the Ministry focused on the important side effects of these cluster antibiotics on the musculoskeletal system and stated that these risks, which can lead to disability when used in easy infections, may preclude the benefits for treatment. It was emphasized that it should not be considered as first-line treatment. These new studies show that there are also risks for the cardiovascular system.
It changes DNA!
The latest research on the subject, published in JAMA, is from the Division of Cardiac and Lung Surgery from Baylor College of Medicine and the Cardiovascular Research Institute and the Cardiovascular Surgery Division of the Texas Heart Institute and Stem Cell Research Unit. A collaborative effort by people. According to the study based on mouse experiments, antibiotics with these active elements initiate many negative reactions by causing damage to the cell’s nucleus and mitochondrial DNA.
These reactions also cause rupture of the aneurysm in mice with aortic aneurysm, and thinning and ballooning of the aorta, in other words, triggering the formation of aneurysm in mice with symptoms such as high blood pressure and predisposition to aortic aneurysm. The vascular walls of blood pressure patients are essentially thinned. In other words, the susceptibility of these patients to aortic aneurysm is essentially high. On top of that, the use of these drugs can trigger ruptures, that is, fatal aneurysm bleeding. According to the study, this cluster of antibiotics doubles the risk.
FAMILY DOCTORS AND EMERGENCY DOCTORS SHOULD BE VERY CAREFUL!
Doctors (especially family doctors or emergency physicians) should definitely do an antibiogram and prescribe antibiotics accordingly before starting antibiotics for the patient who has come with signs of infection. If this is not possible at that moment, the risk factors in the family and the patient should be questioned. These antibiotics should not be the primary choice fluoroquinolone cluster, even if the patient has a random history of high blood pressure, diabetes, sudden death, aortic rupture, ballooning of the aorta (aneurysm), blood pressure-related stroke, blood pressure-related brain aneurysm, fainting, aortic failure. Even if there is no other option, patients should be followed closely while using these antibiotics.
Has a fatal risk
Aortic aneurysm ruptures occur in 5 out of every 100,000 people, that is, although rare, 40 percent of these events unfortunately die before they even reach the hospital. Fifty percent of the patients who can be transported to the hospital die in the first 48 hours. Explaining that it is seen twice more in men than in women, Prof. Dr. İhsan Bakır concluded his words as follows: “The group of acute (suddenly developing) patients is usually 50-55 years old. It progresses with signs of heart failure, chest pain, severe back pain. Patients often apply with the words ‘I have a very severe, tearing pain’.” spoke form.
