Recent research results show that ghrelin (hunger hormone) can encourage you to eat favorite foods after meals, even if you are not hungry
. Excessive or untimely secretion of the hormone ghrelin
can cause this.
In experiments, it was observed that people who were given ghrelin hormone from the outside ate much more than usual
, and they continued to eat even though they were full
. It is a 28 amino
acid lipopeptide hormone that plays a role in the regulation of appetite and body weight by influencing
. In addition to being produced in the fundus part of the stomach
, it is also produced to a lesser extent by the intestine, kidney, pituitary gland, placenta,
prostate, testis, brain, and hypothalamus.
After being produced in the stomach, it reaches its receptors
in the anterior pituitary and hypothalamic region, stimulating GH (growth hormone) release, regulating power stability and nutrient intake
. While it increases in the fasting state, it decreases after the meal
. It transmits information to the brain
that increases food intake and adipose tissue. In anorexia nervosa and in the growth period, blood
levels are high. It also prevents the draining of power stores and cachexia
.
Ghrelin, which is the hunger hormone given exogenously, increases food intake
in mice, decreases fat use and ultimately causes an increase in adipose tissue
.
Jeffrey Zigman of the University of Texas
Southwestern Medical Center, who has worked on overcoming addiction with the addiction cycle, said that ghrelin
, which has a key role in appetite, is also associated with the reward center and it leads to more food. He said that he encouraged
. Another reason for overeating is that ghrelin may be associated with excessive release of ghrelin
.
Lifestyle is one of the factors affecting ghrelin levels.
It is known that chronic insomnia causes excessive ghrelin secretion.
This can be the answer to why trying to maintain life with little sleep daily
causes an increase in weight.
It has also been confirmed in studies that ghrelin is associated with the hormones leptin, cholecystokinin and insulin
, which are active in appetite control.
In an experiment, it was observed that ghrelin hormone levels in the blood
of individuals who were given externally insulin hormone decreased rapidly, and when insulin support ended
, ghrelin hormone levels returned to normal. The hormone insulin
works to lower blood glucose
, which rises quickly after meals. In such a case, it is necessary to decrease the ghrelin hormone
because ghrelin works to increase blood glucose.
Considering that insulin increases the levels of the satiety hormone “leptin”
, the importance of insulin hormone in controlling appetite
is understood.
Leptin and BMI were found to be of positive interest in the middle around the waist and around the hips.
Negative correlation
was detected between Girelin and mid-waist circumference and waist/hip ratio. Most of the leptin hormone is synthesized in adipose tissue;
individuals participating in the study had a decrease in leptin levels in parallel with the decrease in body fat mass
together with weight loss. An increase in serum ghrelin levels is observed with weight loss
, but this increase is not significant
, indicating that ghrelin levels may change not only depending on weight changes, but also
individual dietary habits and environmental factors.
suggests. The fact that ghrelin is a hormone that shows rapid changes
in short time intervals also supports this situation.
Measures to be taken
as more research is needed on the issue:
Attention should be paid to regular sleep cycles.
Starting from infancy and childhood, enabling individuals to adapt to a healthy
diet and healthy lifestyle is the gold standard in this
issue.
A healthy diet and systematic exercise
should be carried out together in achieving a healthy weight.
Efforts to bring formula foods closer to breast milk should continue
. (It is known that formula-fed babies are more obese in the later
periods of their lives. After the first month
, they gain more weight compared to AS-fed babies. The high levels of ghrelin and leptin
suggest that these hormones pass to the baby through breast milk
and play a role in the regulation of power stability in the next period
.
may be related to the content of formula foods or bottle feeding
.
Even if there are hormonal reasons for consuming a lot of carbohydrates, if the individual can provide self-control
it is possible to deal with this situation
.
