NEW CAUSE OF HIGH PLASMA TRIGLYCERIDES DISCOVERED
Hypertriglyceridemia is a lipid metabolism disorder resulting from oversynthesis, defective processing and clearance, or both. Dietary triglycerides are absorbed from the small intestine and secreted into the lymphatic system. Although more than one of the triglycerides in the blood are absorbed from the small intestine, the liver also produces a measure of triglycerides and gives them to the blood.
The determination of hypertriglyceridemia as a risk factor for the development of CVD, especially recently, and knowing that it plays a valuable role in the development of acute pancreatitis and non-alcoholic (non-alcoholic) steatohepatitis (liver fat) for years reveals the necessity of its treatment. Hypertriglyceridemia is mostly caused by uncontrolled diabetes, uncontrolled sugary foods, high fructose intake and obesity. Elevated plasma triglyceride levels can also be caused by mutations in various genes that regulate triglyceride metabolism. However, despite years of research and an increasing understanding of triglyceride metabolism, many events of hypertriglyceridemia are not fully understood.
We always advise individuals with high triglyceride levels to diet, exercise and avoid high-fat foods. However, this did not affect some patients and the reason was not revealed. In a study conducted by the University of California, researchers argue that a syndrome called ‘GPIHBP1 autoantibody syndrome’ is a valuable advance in hypertriglyceridemia.
Triglycerides in the blood circulation are broken down by enzymes called lipoprotein lipase in the capillary. However, it has been observed that autoantibodies against GPIHBP1 prevent the digestion of triglyceride by inhibiting the activity of triglyceride-degrading (digesting) lipoprotein lipase. autoantibodies were formed in the baby by passing through the placenta of the pregnant person and entered the baby’s circulation. And as a result, severe triglyceride elevation (hypertriglyceridemia) developed in the baby. With the disappearance of the mother’s wasted autoantibodies, the baby’s triglyceride level returned to normal.
Research The researchers said that more research will be needed to define the frequency of GPIHBP1 autoantibody syndrome and how it can be treated, but immunosuppressive drugs can help reduce autoantibodies and lower plasma triglyceride levels.
Deputy chief of atherothrombosis and coronary artery disease of the National Heart, Lung and Blood Institute, Dr. “The researchers not only discovered a new disease, but their findings suggested it was curable,” said Michelle Olive. example.” They said.
